Safety- If you are operating a company, especially a home based business, do not use your home as your address. Depending upon your product/service you can make yourself vulnerable to those who would seek to violate your privacy. There is a reason addresses are not on sites like Facebook, it isn't who you know - its who you don't.
In that same thought, P.O boxes and even national virtual offices give the consumer the feeling that you are only there temporarily. Find a place that allows your business to look established. Our address tells someone whether you are an established company.
How your client feels when they walk into your office sets the tone for the meeting. Our offices are purposefully built with a home feeling for ultimate comfort.